No problem using them, just be sure to triple rinse them. I like to use a cup of ammonia in them, with a gallon of water, shake it around a bit, pressurize it and then spray until the line is clear. Rinse out with water, and repeat pressurization and spray, then dispose of the rinsate. I always store my sprayers with at least 1/2 gallon of water in them, it helps keep the seals in good shape. I have a Roundup pump sprayer that I use specifically for roundup, and I use a Chapin 2 gallon can for other stuff.